Generally, drugs are an extremely uncertain method of suicide because of differing drug action in different people. The LD-50 can be regarded as a very bare minimum; that is, below that, sure, you -could- wind up dead, but there's a damn good chance you'll wake up some hours later strapped to a gurney in the psychiatric section of a hospital emergency department.
LD-50's mentioned in posts on a.s.h or associated lists / chats:
|Acetaminophen (paracetamol)||338 oral, 500 i.p.||Generally takes about 2 weeks to die, usually in great pain from kidney and liver failure.|
|Ambien (zolpidem tartrate)||?||"Individuals have fully recovered from ODs up to 400 mg"|
|anecdotal report of successful suicide showed 23.6 mg/L of clozapine in cardiac blood (Canadian Soc. of Forensic Science)|
|Darvon (propoxyphene-d-HCL)||282||note that the propoxyphene is just one ingredient in darvon|
|Darvon-N (propoxyphene-d-napsylate monohydrate)||990||note that the propoxyphene is just one ingredient in darvon-n|
|desipramine||500||chloroquinine acts as an -antidote-!|
|Alcohol, chloral hydrate, diazepam, amobarbital, chordiazepoxide, meprobamate increase chances of death|
|Dextromethorphan Hydrobromide (DXM; found in Robitussin DM)||
|Merck does not report an LD-50. The DXM FAQ reports one suicidal success, but this could have been a simple allergic reaction. A death was also reported on the newsgroup involving a cocktail including DXM, but given the number of different drugs involved it is difficult to tell if the DXM had any contributory effect.|
|Diethylpropion HCl (Tenuate)||
|Persons who have regularly taken amphetamines have a much higher tolerance. This drug is available through some online pharmacies.|
|LD-50 on injection, as with many drugs, is lower by a factor of ten . http://www.vh.org//Providers/Conferences/CPS/31.html reports an LD-50 of approx. 35 mg/kg, which correlates more closely with the Merck i.p. LD-50 of 65 mg/kg. The above webpage also says that patients have "survived ingetstions of 10g".|
11.2 i.v. / 62 s.c.
|Hydrocodone (Bekadid, Dicodid)||
|Iron (ferrous sulfate)||1520||causes death by painful internal bleeding, over a period of several days|
|Lithonate / Camcolit / Candamide (lithium carbonate)||710||obtainable from some art supply stores - used to make ceramic glazes|
|Lopressor (metoprolol tartrate)||3090||higher doses spread out to less vital muscle rather than concentrating in cardiac tissue|
|LSD (Lysergide)||i.v. in mice, 46;
i.v. in rabbits, 0.3
|Lethal OD unlikely from psychoactives as one is likely to trip out before taking a lethal oral dose. The possibility of dying from jumping off a building while tripping does exist. LSD is a serotonin antagonist.|
|MDMA HCl (Ecstasy)||97 i.p.||"although MDMA is more toxic than, say, the cactus-based psychedelic mescaline, it would take a big dose of e, something like 14 of today's purest pills ingested at once, to kill you." (Time Magazine, May 2000))|
|Meprobamate (Miltown)||800 i.p.||"Death has been reported with ingestion of as little as 12 g meprobamate and survival with as much as 40 g"|
|Methadone HCl||95||"Respiratory arrest, shock, and cardiac arrest have occurred."|
|Morphine Sulfate||?||One asher successfully suicided with a friend, each taking 800 mg of Morphine i.v.|
|Norval / Tolvin (mianserin HCL)||390|
|Roxicet tablets contain 5 mg oxycodone in each tablet|
|phentermine (Ionamin)||20*||Persons who have regularly taken amphetamines have a much higher tolerance.|
|Restoril (temazepam)||1963*||LD-50 >2400 in rabbits|
|ricin||.001||takes two days or more to die from painful and massive internal hemorraging; more strictly restricted in the US than heroin; Click here for Cornell Univ. summary|
|Risperdal||??||"doses ranging from 20 to 300 mg involved no fatalities"|
|Seconal (secobarbital sodium)||125||prescribing info from Lilly indicates a fatal blood level is between 15µg/ml and 40µg/ml.|
|Tofranil (impiramine HCL)||
|Zoloft (sertraline HCL)||?||as of late 1992, there were no reports of death from OD'ing on Zoloft alone, but there were four known deaths involving Zoloft and other drugs or alcohol.|
Unless indicated with an asterisk, LD-50 cites are as indicated in the Merck Index, 11th edition, Merck Sharp & Dohme, Rahway, NJ, USA.
Desyrel information is from the prescribing information of
Apothecon Corp. The primary source for the Manerix information is unknown.
Restoril information is from the prescribing information of Sandoz Corp.
Risperdal information is from the prescribing information of Janssen
All LD-50's above are oral unless otherwise indicated. This is because it is
usually extremely difficult to obtain a pure i.v. version of a drug.
i.v. = intravenous (injected into a vein); s.c. = subcutaneous (injected below the skin); i.p. = interperitoneal (injected into the peritoneum).
HCL = Hydrochloride
Poison Information Links
Detailed psychiatric drug information, including links to research studies, are available at a site called Internet Mental Health.
Links to Government/University Poison Information Sites:
|Canadian poisonous plants information system||Georgia Poison Center|
|Indiana Toxic Plants Indicies||Poisonous Plants and Mushrooms of North Carolina|
|Toxicity of plants-Safety info-Wellness Center||International Programme on Chemical Safety|